Meli Cafe is one of The 9 Best American Restaurants in South Loop, Chicago.

1. Meli Cafe

8.3
500 S Dearborn St, Chicago, IL
American Restaurant · Printer's Row · 49 tips and reviews

Vicki G.Vicki Gerentes: Great breakfast bowls and delicious Nutella crepes!

Marsha K.Marsha K.: Vegan French toast is awesome.

Jamel M.Jamel Moyer: Great food and fast service

Woven & Bound - Marriott Marquis Chicago is one of The 9 Best American Restaurants in South Loop, Chicago.

2. Woven & Bound - Marriott Marquis Chicago

7.9
2121 S Prairie Ave (Calumet), Chicago, IL
American Restaurant · South Loop · 2 tips and reviews

Tony B.Tony Burkhart: Everything was perfect!

edisonv 😜edisonv 😜: Dessert plates

Half Sour is one of The 9 Best American Restaurants in South Loop, Chicago.

3. Half Sour

7.8
755 S Clark St (at Polk St), Chicago, IL
American Restaurant · Dearborn Park · 9 tips and reviews

Elena Jacobs L.Elena Jacobs Lopez: Drinks are inventive, bagels are made in house, definitely will return to try lunch or dinner

Rico C.Rico Cammon: Awesome menu!

Scott S.Scott Sachnoff: 12 beers on draft - $2 off on Wednesdays

S.R.O. - Standing Room Only is one of The 9 Best American Restaurants in South Loop, Chicago.

4. S.R.O. - Standing Room Only

7.6
610 S Dearborn St (at W Harrison St), Chicago, IL
American Restaurant · Printer's Row · 25 tips and reviews

Big M.Big Mark: Bacon Cheeseburger is a GO!!! Fresh, flavorful and that's just the bun lol. Definitely in the top 10 of burger places in Chicago

Kevin H.Kevin Higgins: Food is good. Service is not the friendliest. Worth stopping in if you need a bit to eat and are in the area.

Radim S.Radim SVOBODA: The home made hummus is nowhere close to the Mediterranean hummus, so beware. But the burgers are worth its name.

Little Branch Cafe South Loop is one of The 9 Best American Restaurants in South Loop, Chicago.

5. Little Branch Cafe South Loop

7.7
1251 S Prairie Ave (at S. Indiana Ave.), Chicago, IL
American Restaurant · South Loop · 44 tips and reviews

Loria N.Loria Near: The breakfast fritatta was delicious but huge! Well worth the money and friendly staff as well.

Roosevelt CollectionRoosevelt Collection: If you're drinking, get the Sangria. If you're recovering from drinking, try their coffee. Both are fabulous.

StephenStephen: Here for breakfast, but love the turkey reuben.

720 South Bar & Grill is one of The 9 Best American Restaurants in South Loop, Chicago.

6. 720 South Bar & Grill

8.3
720 S Michigan Ave (Hilton Chicago), Chicago, IL
Hotel Bar · South Loop · 10 tips and reviews

Kelly G.Kelly Gotkin: Fantastic breakfast buffet. Excellent scrambled eggs.

Ludo R.Ludo Raedts: Always bring your ID if you want to drink alcohol. Even when your 40...

Antonia M.Antonia Maycunich: If you sit at the bar, you 100% will have the best experience with Angel & Steve. Clearly 2 gentlemen who love their jobs and love people. They are absolutely wonderful.

Weather Mark Tavern is one of The 9 Best American Restaurants in South Loop, Chicago.

7. Weather Mark Tavern

8.1
1503 S Michigan Ave, Chicago, IL
Bar · South Loop · 66 tips and reviews

Lee SLee S: Yummy fall off the bone ribs with a not too sweet sauce! The pigs in a blanket were awesome too!

StephenStephen: Check out the six new taps at Weather Mark! Awesome.

Mark S.Mark Stern: Follow us on twitter @weathermarktav

The Burger Point is one of The 9 Best American Restaurants in South Loop, Chicago.

8. The Burger Point

7.8
1900 S State St (Archer & State), Chicago, IL
Burger Joint · South Loop · 59 tips and reviews

Jenny C.Jenny Ch: Love the spicy garlic wings! Very BW3-esque. Yum.

Time Out ChicagoTime Out Chicago: What no one tells you is that the burgers are de facto cooked to medium-well, and that the signature item—the Burger Point Burger with roasted chili peppers—is hot enough to burn your face off. Read more.

MrsShawnaBMrsShawnaB: They sell Flirty Cupcakes… Can you say win-win! ;-)

The Spoke & Bird is one of The 9 Best American Restaurants in South Loop, Chicago.

9. The Spoke & Bird

8.2
205 E 18th St (at S Indiana Ave), Chicago, IL
Bistro · Prairie District · 19 tips and reviews

FilippaFilippa: I had the pasta carbonara and I loved it!!! Lovely bistro 🌿❤️👌

Ryan F.Ryan Foltz: Coffee is very good, tried the jam burger, also very good!

Angie O.Angie Osmanski: Great turkey burger! They use local farms for all of their food. Everything is delicious but it's also very expensive.